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Hormones/Immunology

Functional Adrenal Cortisol Rhythm w/ sIgA x 4
Functional Adrenal Stress Profile w/ sIgA x 4
Functional Adrenal Stress Profile II w/ sIgA x 4
Functional Adrenal Stress Profile plus III w/ sIgA x 4
Functional Adrenal Stress Profile plus V w/ sIgA x 4

Functional Adrenal Stress Profile w/ sIgA x 4, #201-S

4 cortisol, 2 averaged DHEA-S; Secretory IgA x 4; includes 1-Day Patient Diary

  • Turnaround: 3 - 4 days
  • 4 Cortisol and 2 averaged DHEA-S

This profile is clinically indicated to evaluate an individual’s ability to adapt to environmental, mental, emotional, and physiological stressors. Because Cortisol and DHEA are involved in virtually every aspect of bodily function modulation, it is recommended as an entry-level test and is generally combined with profile #101.

The Functional Adrenal Stress Profile measures the adrenal rhythm and the DHEA-S -to-Cortisol ratio. An abnormal adrenal rhythm can negatively influence energy production; immune system health; skin regeneration; muscle and joint function; bone health; sleep quality; and liver, pancreas, and thyroid function.

Adrenal dysfunction may be associated with the following symptoms: excessive fatigue; chronic stress and related health problems; dizziness upon standing; weakness; hypoglycemia; nervousness; irritability; depression; inability to concentrate; confusion; poor memory; low blood pressure; insomnia; premenstrual tension; sweet cravings; headaches; alcohol intolerance; excessive hunger; alternating diarrhea and constipation; Sternocleidomastoid/trapezius pain and spasms; epigastric discomfort; poor resistance to infection; food and/or inhalant allergies; dyspepsia; tenderness in adrenal area; migraine headaches; low body temperature; and diminished sex drive.

SUMMARY: Evaluating the Cortisol circadian (24-hour) rhythm along with DHEA-S provides an accurate assessment of adrenal function and can reveal maladaptation to stressors. Saliva (free fraction) testing determines the bioactive level of these hormones at the cellular level, thereby providing a functional assessment of the effects of environmental and physiological stressors.

Mucosal Immunity Profile

Highlights

  • Measures sIgA, the primary measurement for first line immune defense (mucosal immunity)
  • Can determine possible infections, reactions to foods, and environmental toxins
  • Can be correlated with the Functional Adrenal Stress Profile to compare sIgA with each cortisol level to further enhance the interpretation relative to lifestyle (clinical and subclinical sources of chronic stress), adrenal function and first-line immunity.

Overview
An overall deficiency of sIgA (low sIgA average) indicates increased risk for infections, reactions to foods and environmental toxins. An overall increase of sIgA (high sIgA average) indicates an acute response to infection, i.e. bacteria, parasites, viral, yeasts, or fungal. Lifestyle factors can dramatically affect sIgA output therefore correlating the 1-Day Patient Diary with the test results provides greater clinical relevance, enhances patient compliance, and health care outcomes.

Selective Diseases in Secretory IgA Deficiency

  • Autoimmune achlorhydria, pernicious anemia, villous atrophy
  • Infectious Clostridium, Giardia, Cryptosporidium parvum, Helicobacter pylori, Salmonella
  • Inflammatory celiac, Crohn’s, ulcerative colitis
  • Neoplastic lymphoma, stomach adenocarcinoma

How it Works
Saliva samples are collected over the course of one day. This should be on a typical day. This profile can be added on to any Functional Adrenal Stress Profile. Correlating each sIgA with individual cortisol samples greatly enhances the ability to apply the data relative to adrenal health, immunity, and lifestyle factors. Collection times are the same as the Functional Adrenal Stress Profiles.


Additional Resources:
Diagram: Physiological Aspects of Cortisol and DHEA
Normal and Abnormal Values: Metabolic Assessment Profile & Functional Adrenal Stress Profile
Bibliography on Efficacy of Salivary Testing