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Hormones/Immunology

Functional Adrenal Cortisol Rhythm w/ sIgA x 4
Functional Adrenal Stress Profile w/ sIgA x 4
Functional Adrenal Stress Profile II w/ sIgA x 4
Functional Adrenal Stress Profile plus III w/ sIgA x 4
Functional Adrenal Stress Profile plus V w/ sIgA x 4

Functional Adrenal Stress Profile w/ sIgA x 4, #204-S

  • Turnaround: 3 - 4 days
  • 4 Cortisol

This profile is clinically indicated to evaluate an individual’s ability to adapt to environmental, mental, emotional, and physiological stressors. It is recommended for children, as well as for baseline and follow-up monitoring of Adrenal Cortisol Rhythms in individuals of all ages.

Functional Adrenal Cortisol Rhythm provides an assessment of adrenal rhythm and is appropriate for children 14 years of age and younger. DHEA is not produced in clinically significant levels in children less than 14 years of age and its augmentation is not applicable. Therefore, DHEA is not included in an adrenal assessment of young people (as it is in profile #201).

Abnormal adrenal rhythm can negatively influence energy production; immune system health; skin regeneration; muscle and joint function; bone health; sleep quality; and liver, pancreas and thyroid function.

SUMMARY: Evaluating the Cortisol circadian (24-hour) rhythm along with DHEA-S provides an accurate assessment of adrenal function and can reveal maladaptation to stressors. Saliva (free fraction) testing determines the bioactive level of these hormones at the cellular level, thereby providing a functional assessment of the effects of environmental and physiological stressors.

Mucosal Immunity Profile

Highlights

  • Measures sIgA, the primary measurement for first line immune defense (mucosal immunity)
  • Can determine possible infections, reactions to foods, and environmental toxins
  • Can be correlated with the Functional Adrenal Stress Profile to compare sIgA with each cortisol level to further enhance the interpretation relative to lifestyle (clinical and subclinical sources of chronic stress), adrenal function and first-line immunity.

Overview
An overall deficiency of sIgA (low sIgA average) indicates increased risk for infections, reactions to foods and environmental toxins. An overall increase of sIgA (high sIgA average) indicates an acute response to infection, i.e. bacteria, parasites, viral, yeasts, or fungal. Lifestyle factors can dramatically affect sIgA output therefore correlating the 1-Day Patient Diary with the test results provides greater clinical relevance, enhances patient compliance, and health care outcomes.

Selective Diseases in Secretory IgA Deficiency

  • Autoimmune achlorhydria, pernicious anemia, villous atrophy
  • Infectious Clostridium, Giardia, Cryptosporidium parvum, Helicobacter pylori, Salmonella
  • Inflammatory celiac, Crohn’s, ulcerative colitis
  • Neoplastic lymphoma, stomach adenocarcinoma

How it Works
Saliva samples are collected over the course of one day. This should be on a typical day. This profile can be added on to any Functional Adrenal Stress Profile. Correlating each sIgA with individual cortisol samples greatly enhances the ability to apply the data relative to adrenal health, immunity, and lifestyle factors. Collection times are the same as the Functional Adrenal Stress Profiles.


Additional Resources:
Diagram: Physiological Aspects of Cortisol and DHEA
Bibliography on Efficacy of Salivary Testing