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- Specimen: Blood
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ANTI-GLIADIN ANTIBODY, IgA: Gliadin IgA is an enzyme-linked
immunosorbent assay (ELISA) for the detection of Gliadin IgA
antibodies. Detection of these antibodies is an aid in the
diagnosis of certain gluten sensitive enteropathies such as
celiac disease and herpetiformis. Celiac disease or gluten
sensitive enteropathy is a chronic condition with features
including inflammation and characteristic histological "flattening"
of intestinal mucosa resulting in malabsorption of nutrients.
ANTI-GLIADIN ANTIBODY, IgG: Gliadin IgG is an enzyme-linked
immunosorbent assay (ELISA) for the detection of Gliadin IgG
antibodies. Detection of these antibodies is an aid in the
diagnosis of certain gluten sensitive enteropathies such as
celiac disease and herpetiformis. Celiac disease or gluten
sensitive enteropathy is a chronic condition with features
including inflammation and characteristic histological "flattening"
of intestinal mucosa resulting in a malabsorption of nutrients.
Measuring both Anti-gliadin IgA & IgG provides a significantly
higher degree of detection.
ANTI-TRANSGLUTAMINASE ANTIBODY, IgA: Human tissue
transglutaminase is an enzyme-linked immunosorbent assay (ELISA)
for the detection of IgA antibodies to tissue transglutaminase
(endomysium). Detection of these antibodies is an aid in diagnosis
of certain gluten sensitive enteropathies such as celiac disease
and dermatitis herpetiformis. Celiac disease and dermatitis
herpetiformis, two recognized forms of gluten sensitive enteropathy
(GSE) are characterized by chronic inflammation of the intestinal
mucosa and flattening of the epithelium or positive "villous
atrophy". Intolerance to gluten (gliadin), the protein
found primarily in grains such as wheat, rye and barley causes
GSE. Patients with celiac disease may suffer from diarrhea,
gastrointestinal problems, anemia, fatigue, psychiatric problems
and other diverse side effects or they may be asymptomatic.
Dermatitis herpetiformis is a skin disease associated with
GSE. All GSE patients have an increased risk of lymphoma.
A gluten-free diet controls GSE and substantially reduces
the associated risks.
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